Equine Asthma: Current Understanding and Future Directions

Laurent Couetil; Jacqueline M Cardwell; Renaud Leguillette; Melissa Mazan; Eric Richard; Dorothee Bienzle; Michela Bullone; Vinzenz Gerber; Kathleen Ivester; Jean-Pierre Lavoie; James Martin; Gabriel Moran; Artur Niedźwiedź; Nicola Pusterla; Cyprianna Swiderski

doi:10.3389/fvets.2020.00450

Equine Asthma: Current Understanding and Future Directions

Front Vet Sci. 2020 Jul 30:7:450. doi: 10.3389/fvets.2020.00450. eCollection 2020.

Authors

Affiliations

¹ College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.
² Department of Pathobiology and Population Sciences, Royal Veterinary College, London, United Kingdom.
³ College of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
⁴ Cummings School of Veterinary Medicine, Tufts University, Grafton, MA, United States.
⁵ LABÉO (Frank Duncombe), Normandie Université, UniCaen, Caen, France.
⁶ Department of Pathobiology, University of Guelph, Guelph, ON, Canada.
⁷ Department of Veterinary Sciences, University of Turin, Grugliasco, Italy.
⁸ Vetsuisse Faculty, Institut Suisse de Médecine Équine (ISME), University of Bern and Agroscope, Bern, Switzerland.
⁹ Faculty of Veterinary Medicine, University of Montreal, Montreal, QC, Canada.
¹⁰ Meakins Christie Laboratories, McGill University Health Center Research Institute, Montreal, QC, Canada.
¹¹ Department of Pharmacology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
¹² Department of Internal Diseases With Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wrocław, Poland.
¹³ Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
¹⁴ College of Veterinary Medicine, Mississippi State University, Starkville, MS, United States.

Abstract

The 2019 Havemeyer Workshop brought together researchers and clinicians to discuss the latest information on Equine Asthma and provide future research directions. Current clinical and molecular asthma phenotypes and endotypes in humans were discussed and compared to asthma phenotypes in horses. The role of infectious and non-infectious causes of equine asthma, genetic factors and proposed disease pathophysiology were reviewed. Diagnostic limitations were evident by the limited number of tests and biomarkers available to field practitioners. The participants emphasized the need for more accessible, standardized diagnostics that would help identify specific phenotypes and endotypes in order to create more targeted treatments or management strategies. One important outcome of the workshop was the creation of the Equine Asthma Group that will facilitate communication between veterinary practice and research communities through published and easily accessible guidelines and foster research collaboration.

Keywords: biomarkers; endotype; heaves; inflammatory airway disease; phenotype; recurrent airway obstruction.

Publication types

Review