RNA Splicing: Basic Aspects Underlie Antitumor Targeting

Recent Pat Anticancer Drug Discov. 2020;15(4):293-305. doi: 10.2174/1574892815666200908122402.

Abstract

Background: RNA splicing, a fundamental step in gene expression, is aimed at intron removal and ordering of exons to form the protein's reading frame.

Objective: This review is focused on the role of RNA splicing in cancer biology; the splicing abnormalities that lead to tumor progression emerge as targets for therapeutic intervention.

Methods: We discuss the role of aberrant mRNA splicing in carcinogenesis and drug response.

Results and conclusion: Pharmacological modulation of RNA splicing sets the stage for treatment approaches in situations where mRNA splicing is a clinically meaningful mechanism of the disease.

Keywords: Cancer; RNA splicing; molecular drug targets; protein kinase inhibitors.; therapy.

Publication types

  • Review

MeSH terms

  • Drug Resistance, Neoplasm*
  • Exons
  • Humans
  • Introns
  • Mutation*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Patents as Topic
  • Phosphotransferases
  • RNA Splicing Factors / antagonists & inhibitors*
  • RNA Splicing Factors / metabolism
  • RNA Splicing*
  • RNA, Messenger*

Substances

  • RNA Splicing Factors
  • RNA, Messenger
  • Phosphotransferases