Narrative review on potential role of gut microbiota in certain substance addiction

Chenyuan Qin; Jiawei Hu; Yiming Wan; Mengyao Cai; Zhenting Wang; Zhao Peng; Yuxiao Liao; Dan Li; Ping Yao; Liegang Liu; Shuang Rong; Wei Bao; Guifeng Xu; Wei Yang

doi:10.1016/j.pnpbp.2020.110093

Narrative review on potential role of gut microbiota in certain substance addiction

Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2:106:110093. doi: 10.1016/j.pnpbp.2020.110093. Epub 2020 Sep 6.

Authors

Chenyuan Qin¹, Jiawei Hu¹, Yiming Wan¹, Mengyao Cai¹, Zhenting Wang¹, Zhao Peng¹, Yuxiao Liao¹, Dan Li¹, Ping Yao¹, Liegang Liu¹, Shuang Rong², Wei Bao³, Guifeng Xu⁴, Wei Yang⁵

Affiliations

¹ Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Wuhan, China; Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Wuhan, China.
² Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Wuhan, China; Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Wuhan, China; Department of Nutrition and Food Hygiene, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.
³ Department of Epidemiology, College of Public Health, University of Iowa, IA 52242, USA.
⁴ Department of Epidemiology, College of Public Health, University of Iowa, IA 52242, USA; Center for Disabilities and Development, University of Iowa Stead Family Children's Hospital, Iowa City, IA 52242, USA.
⁵ Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Wuhan, China; Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Wuhan, China. Electronic address: yw8278@hust.edu.cn.

PMID: 32898589
DOI: 10.1016/j.pnpbp.2020.110093

Abstract

As a neuropsychiatric disorder, substance addiction represents a major public health issue with high prevalence and mortality in many countries. Recently, gut microbiota has been certified to play a part in substance addiction through various mechanisms. Hence, we mainly focused on three substance including alcohol, cocaine and methamphetamine in this review, and summarized their relationships with gut microbiota, respectively. Besides, we also concluded the possible treatments for substance addiction from the perspective of applying gut microbiota. This review aims to build a bridge between substance addiction and gut microbiota according to existing evidences, so as to excavate the possible bi-directional function of microbiota-gut-brain axis in substance addiction for developing therapeutic strategies in the future.

Keywords: Addiction; Alcohol; Cocaine; Gut microbiota; Methamphetamine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alcoholism / complications
Alcoholism / metabolism
Brain-Gut Axis / drug effects
Brain-Gut Axis / physiology*
Cocaine / adverse effects
Dysbiosis / complications
Dysbiosis / diet therapy
Dysbiosis / metabolism*
Gastrointestinal Microbiome / drug effects
Gastrointestinal Microbiome / physiology*
Humans
Methamphetamine / adverse effects
Prebiotics / administration & dosage
Probiotics / administration & dosage
Substance-Related Disorders / complications
Substance-Related Disorders / diet therapy
Substance-Related Disorders / metabolism*

Substances

Prebiotics
Methamphetamine
Cocaine

Grants and funding

P30 ES005605/ES/NIEHS NIH HHS/United States