Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

Cell Mol Immunol. 2020 Oct;17(10):1095-1097. doi: 10.1038/s41423-020-00523-5. Epub 2020 Sep 7.

Authors

Yang Li^#¹, Dan-Yun Lai^#¹, Hai-Nan Zhang^#¹, He-Wei Jiang^#¹, Xiaolong Tian^#², Ming-Liang Ma¹, Huan Qi¹, Qing-Feng Meng¹, Shu-Juan Guo¹, Yanling Wu², Wei Wang³, Xiao Yang⁴, Da-Wei Shi⁵, Jun-Biao Dai⁶, Tianlei Ying⁷, Jie Zhou⁸, Sheng-Ce Tao⁹

Affiliations

¹ Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, China.
² MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, 200032, Shanghai, China.
³ Foshan Fourth People's Hospital, 528000, Foshan, China.
⁴ Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
⁵ National Institutes for Food and Drug Control, Tiantan Xili #2, Beijing, China.
⁶ CAS Key Laboratory of Quantitative Engineering Biology, Guangdong Provincial Key Laboratory of Synthetic Genomics and Shenzhen Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
⁷ MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, 200032, Shanghai, China. tlying@fudan.edu.cn.
⁸ Foshan Fourth People's Hospital, 528000, Foshan, China. zjet65@163.com.
⁹ Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, China. taosc@sjtu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing / chemistry*
Antibodies, Neutralizing / genetics
Antibodies, Neutralizing / immunology
Antibodies, Viral / chemistry*
Antibodies, Viral / genetics
Antibodies, Viral / immunology
B-Lymphocytes / immunology*
B-Lymphocytes / virology
Betacoronavirus / genetics
Betacoronavirus / immunology*
Betacoronavirus / pathogenicity
Binding Sites
COVID-19
Convalescence
Coronavirus Infections / immunology*
Coronavirus Infections / virology
Epitope Mapping
Epitopes / chemistry*
Epitopes / genetics
Epitopes / immunology
Gene Expression
Host-Pathogen Interactions / genetics
Host-Pathogen Interactions / immunology
Humans
Immune Sera / chemistry
Immunoconjugates / chemistry
Immunoconjugates / genetics
Immunoconjugates / immunology
Models, Molecular
Neutralization Tests
Pandemics
Pneumonia, Viral / immunology*
Pneumonia, Viral / virology
Protein Array Analysis
Protein Binding
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand
Protein Interaction Domains and Motifs
SARS-CoV-2
Spike Glycoprotein, Coronavirus / chemistry*
Spike Glycoprotein, Coronavirus / genetics
Spike Glycoprotein, Coronavirus / immunology

Substances

Antibodies, Neutralizing
Antibodies, Viral
Epitopes
Immune Sera
Immunoconjugates
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2

Grants and funding

31600672/National Natural Science Foundation of China (National Science Foundation of China)/International