Transfusion support for stem cell transplant recipients

Semin Hematol. 2020 Apr;57(2):51-56. doi: 10.1053/j.seminhematol.2020.07.001. Epub 2020 Jul 19.

Abstract

Hematopoietic stem cell patients regularly require transfusion support. Indications for transfusion in this population are similar to other patients being treated with chemoradiation; however, special considerations must be made in regards to pretransfusion testing, ABO compatibility, product modifications, and anticipated challenges while patients undergo engraftment. Additionally, infusion of hematopoietic stem cells requires acute understanding of product collection, modification, and potential side effects. As these patients often require numerous platelet transfusions, platelet refractoriness may be encountered and practice options are discussed. We review current indications and guidelines for transfusion in hematopoietic stem cell patients and make recommendations for best practice based on current literature.

Keywords: Stem cell transplant recipients; Transfusion support.

Publication types

  • Review

MeSH terms

  • Blood Transfusion / methods*
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans
  • Transplantation Conditioning / methods*