Biodegradable conductive multifunctional branched poly(glycerol-amino acid)-based scaffolds for tumor/infection-impaired skin multimodal therapy

Abstract

The tumor/infection-impaired skin regeneration is still a challenge and the single modal therapy strategy is usually inefficient. Herein, a multimodal tumor therapy and antiinfection method based on the conductive multifunctional poly(glycerol-amino acid)-based scaffolds is reported. The multifunctional conductive scaffolds were formed through the crosslinking between branched poly(glycerol-amino acid), polypyrrole@polydopamine (PPy@PDA) nanoparticles and aldehyde F127 (PGFP scaffolds). PGFP scaffolds possessed controlled electrical conductivity, skin-adhesive behavior, broad-spectrum antibacterial activity, photothermal-responsive drug release and good cytocompatibility. Thus, PGFP scaffolds demonstrated the significant photothermo-chemo tumor and multidrug resistant infection therapy in vitro and in vivo, while promoting granulation tissue formation, collagen deposition, vascular endothelial differentiation and accelerated skin regeneration. This work also firstly demonstrated the important role of multifunctional conductive PPy@PDA nanoparticles in tumor/infection-impaired skin multimodal therapy. This study suggests that efficient multimodal therapy on diseased-impaired skin could be achieved through optimizing the structure and multifunctional properties of biomaterials.

Keywords: Antibacterial activity; Multifunctional biomaterials scaffolds; Multimodal therapy; Tissue engineering; Tumor/infection-impaired skin.