Reinventing Molecular Imaging with Total-Body PET, Part II: Clinical Applications

Babak Saboury; Michael A Morris; Moozhan Nikpanah; Thomas J Werner; Elizabeth C Jones; Abass Alavi

doi:10.1016/j.cpet.2020.06.013

Reinventing Molecular Imaging with Total-Body PET, Part II: Clinical Applications

PET Clin. 2020 Oct;15(4):463-475. doi: 10.1016/j.cpet.2020.06.013.

Authors

Babak Saboury¹, Michael A Morris², Moozhan Nikpanah³, Thomas J Werner⁴, Elizabeth C Jones³, Abass Alavi⁵

Affiliations

¹ Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA; Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore, MD, USA; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
² Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA; Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore, MD, USA.
³ Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
⁴ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
⁵ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA. Electronic address: abass.alavi@pennmedicine.upenn.edu.

Abstract

Total-body PET scans will initiate a new era for the PET clinic. The benefits of 40-fold effective sensitivity improvement provide new capabilities to image with lower radiation dose, perform delayed imaging, and achieve improved temporal resolution. These technical features are detailed in the first of this 2-part series. In this part, the clinical impacts of the novel features of total-body PET scans are further explored. Applications of total-body PET scans focus on the real-time interrogation of systemic disease manifestations in a variety of practical clinical contexts. Total-body PET scans make clinical systems biology imaging a reality.

Keywords: Inflammation imaging; Oncology; Oncoradiology; Total-body PET; Vascular imaging.

Publication types

Review

MeSH terms

Humans
Molecular Imaging / methods*
Positron-Emission Tomography / methods*
Whole Body Imaging / methods*