Moving On after Trauma: Fibroblasts Thrive in the Right Environment

Raul Ramos; Maksim V Plikus

doi:10.1016/j.stem.2020.08.007

Moving On after Trauma: Fibroblasts Thrive in the Right Environment

Cell Stem Cell. 2020 Sep 3;27(3):349-351. doi: 10.1016/j.stem.2020.08.007.

Authors

Raul Ramos¹, Maksim V Plikus²

Affiliations

¹ Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA.
² Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: plikus@uci.edu.

PMID: 32888421
DOI: 10.1016/j.stem.2020.08.007

Abstract

Large skin wounds in adult mice can heal by regenerating new hair follicles and adipocytes in their center. In this issue of Cell Stem Cell, Abbasi et al. (2020) report how typically scar-forming wound fibroblasts enter a transcriptionally distinct single-cell state of competence during regeneration of new hair follicle mesenchyme.

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MeSH terms

Adipocytes
Animals
Cicatrix
Fibroblasts
Hair Follicle*
Mice
Wound Healing*