Emerging cancer therapies and cardiovascular risk

J Thromb Thrombolysis. 2021 May;51(4):837-845. doi: 10.1007/s11239-020-02263-9.

Abstract

The cardiovascular (CV) toxicity profiles of traditional cancer therapies such as anthracyclines and radiation therapy are familiar to many cardiologists. With the development and widespread use of additional cancer therapeutics, CV toxicities related to these agents are becoming more common. Cardiovascular specialists are often integrated into the care team for individuals with cancer and knowledge of the CV toxicities of cancer therapeutics has become essential. In this review, we provide a clinically focused summary of the current data regarding CV toxicities of common cancer therapies and identify potential management strategies for the CV specialist.

Keywords: Androgen deprivation therapy; Cardio-oncology; Cardiovascular toxicity; Immune checkpoint inhibitors; Proteasome inhibitors; Tyrosine kinase inhibitors; Vascular endothelial growth factor inhibitors.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents* / therapeutic use
  • Cardiovascular Diseases* / chemically induced
  • Heart Disease Risk Factors
  • Humans
  • Neoplasms* / drug therapy
  • Risk Factors

Substances

  • Antineoplastic Agents