Calprotectin S100A8/A9, a heterodimer composed of S100A8 and S100A9, is the main component of cytoplasmic proteins in neutrophils. It plays multiple roles in the immuno-inflammatory reactions intracellularly and extracellularly. Recent studies find that S100A8/A9 is closely related with the initiation and progression of periodontal inflammatory diseases. S100A8/A9 is expected to be a new biomarker for diagnosing periodontal inflammatory diseases, monitoring inflammatory activities in patients with periodontitis, evaluating the outcome of periodontal treatments and predicting the susceptibility of individual patient to periodontitis. In this literature review, we summarize the clinical research progress on the relation between S100A8/A9 and periodontal inflammatory diseases.
S100A8/A9蛋白是由S100A8与S100A9蛋白组成的异二聚体，属于钙结合蛋白S100家族，是中性粒细胞的主要胞质蛋白，在免疫炎症反应中发挥多种胞内、胞外的生物学功能。近年研究发现，S100A8/A9与牙周炎症性疾病的发生发展关系密切。S100A8/A9在诊断牙周炎症性疾病、监测牙周炎症活动性、评价牙周治疗效果以及预测牙周炎易感性等方面有望成为新的生物标志物。本文就S100A8/A9蛋白与牙周炎症性疾病关系的临床研究进展作一文献综述。.
Keywords: Calcium-binding proteins; Calgranulin A; Calgranulin B; Gingivitis; Periodontitis.