Heritability of overlapping impulsivity and compulsivity dimensional phenotypes

Sci Rep. 2020 Sep 1;10(1):14378. doi: 10.1038/s41598-020-71013-x.

Abstract

Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive-compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A2 = 0.33), modest additive genetic or common environmental effects for obsessiveness (A2 = 0.25; C2 = 0.23), and moderate effects of common environment (C2 = 0.36) for the general dimension, This general impulsive-compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Adolescent
  • Adult
  • Compulsive Behavior / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Models, Statistical
  • Obsessive-Compulsive Disorder / genetics
  • Phenotype*
  • Risk Factors
  • Self Report
  • Twins, Dizygotic / genetics*
  • Twins, Dizygotic / psychology*
  • Twins, Monozygotic / genetics*
  • Twins, Monozygotic / psychology*
  • Young Adult