This paper concentrates on the global predefined-time synchronization of delayed memristive neural networks with external unknown disturbance via an observer-based active control. First, a global predefined-time stability theorem based on a non-negative piecewise Lyapunov function is proposed, which can obtain more accurate upper bound of the settling time estimation. Subsequently, considering the delayed memristive neural networks with disturbance, a disturbance-observer is designed to approximate the external unknown disturbance in the response system with a Hurwitz theorem and then to eliminate the influence of the unknown disturbance. With the help of global predefined-time stability theorem, the predefined-time synchronization is achieved between two delayed memristive neural networks via an active control Lyapunov function design. Finally, two numerical simulations are performed, and the results are given to show the correctness and feasibility of the predefined-time stability theorem.