Anatomical Versus Non-anatomical Resection for Hepatocellular Carcinoma, a Propensity-matched Analysis Between Taiwanese and Japanese Patients

Shih-Wei Huang; Pei-Yi Chu; Shunichi Ariizumi; Charles Chung-Wei Lin; Hon Phin Wong; Dev-Aur Chou; Ming-Tsung Lee; Hsing-Ju Wu; Masakazu Yamamoto

doi:10.21873/invivo.12078

Anatomical Versus Non-anatomical Resection for Hepatocellular Carcinoma, a Propensity-matched Analysis Between Taiwanese and Japanese Patients

In Vivo. 2020 Sep-Oct;34(5):2607-2612. doi: 10.21873/invivo.12078.

Authors

Shih-Wei Huang^{1

2

3}, Pei-Yi Chu^{4

5

6}, Shunichi Ariizumi⁷, Charles Chung-Wei Lin^{8

9}, Hon Phin Wong^{1

2}, Dev-Aur Chou¹, Ming-Tsung Lee^{10

11}, Hsing-Ju Wu^{10

12}, Masakazu Yamamoto¹³

Affiliations

¹ Division of General Surgery, Department of Surgery, Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
² IRCAD/AITS-Asian Institute of TeleSurgery, Show Chwan Health Care System, Changhua, Taiwan, R.O.C.
³ Division of General Surgery, Department of Surgery, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
⁴ School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan, R.O.C.
⁵ Department of Pathology, Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
⁶ Department of Health Food, Chung Chou University of Science and Technology, Changhua, Taiwan, R.O.C.
⁷ Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
⁸ Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
⁹ School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
¹⁰ Research Assistant Center, Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
¹¹ Department of Nursing, Hungkuang University, Taichung, Taiwan, R.O.C.
¹² Department of Biology, National Changhua University of Education, Changhua, Taiwan, R.O.C.
¹³ Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan yamamoto.masakazu@twmu.ac.jp.

Abstract

Background/aim: The aim of the study was to compare the outcomes of anatomical resection (AR) versus non-anatomical resection (NAR) for Japanese and Taiwanese patients with single, resectable hepatocellular carcinoma (HCC).

Patients and methods: A propensity score matched (PSM) analysis was performed to compare the outcomes of the AR group to those of the NAR group. Tumor size <5 cm, T1 or T2 grade, without evidence of extrahepatic metastasis, invasion of portal or hepatic veins, or direct invasion of adjacent organs, were included in the study.

Results: A total of 385 cases (Taiwanese 105, Japanese 280) were analyzed. After PSM, a total of 152 cases remain (Taiwan and Japan both 76 cases). Disease-free survival (DFS) and overall survival (OS) data were not significantly different between the two groups at 5 years follow-up.

Conclusion: AR of HCC in Japanese patients has a similar 5-year DFS and OS as NAR of HCC in Taiwanese patients.

Keywords: Anatomical resection; Japan; Taiwan; disease-free survival; hepatocellular carcinoma; non-anatomical resection; overall survival; propensity score matched analysis.

MeSH terms

Carcinoma, Hepatocellular* / surgery
Hepatectomy
Humans
Japan
Liver Neoplasms* / surgery
Retrospective Studies
Taiwan / epidemiology
Treatment Outcome