Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus

Octavio Galindo-Hernandez; Jesus Rene Machado-Contreras; Rodrigo Martinez-Corella; Tatiana Romero-Garcia; J Gustavo Vazquez-Jimenez

doi:10.5114/aoms.2020.97970

Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus

Arch Med Sci. 2020 Aug 10;16(5):1226-1228. doi: 10.5114/aoms.2020.97970. eCollection 2020.

Authors

Octavio Galindo-Hernandez¹, Jesus Rene Machado-Contreras¹, Rodrigo Martinez-Corella¹, Tatiana Romero-Garcia², J Gustavo Vazquez-Jimenez¹

Affiliations

¹ Facultad de Medicina Mexicali, Universidad Autonoma de Baja California, Mexico.
² Departamento de Bioquímica, Cinvestav-IPN, Mexico.

Abstract

We examined the association between sarco/endoplasmic reticulum calcium ATPase (SERCA) expression and glycated hemoglobin (HbA_1c) levels since alterations in this protein expression are associated with the genesis of insulin resistance. HbA1c levels and SERCA protein expression from platelets of Mexican patients diagnosed with type 2 diabetes mellitus (T2DM) were analyzed showing lower values of SERCA expression against the normal values we find in healthy people. Interestingly, as diabetes condition got worse; SERCA protein expression decreased gradually until it was undetectable. The results showed an inverse correlation between HbA_1c and SERCA protein expression in T2DM patients. .

Keywords: SERCA; glycated hemoglobin; type 2 diabetes mellitus.