Boron neutron capture therapy for clear cell sarcoma

Takuya Fujimoto; Minoru Suzuki; Tamotsu Sudo; Ikuo Fujita; Toshiko Sakuma; Yoshinori Sakurai; Takanori Hirose; Masayuki Morishita; Takushi Takata; Yuki Tamari; Hiroki Tanaka; Tooru Andoh; Teruya Kawamoto; Hitomi Hara; Naomasa Fukase; Yohei Kawakami; Rika Shigemoto; Tomoyuki Matsumoto; Hideki Ichikawa; Koji Ono; Ryosuke Kuroda; Toshihiro Akisue

doi:10.1016/j.apradiso.2020.109324

Boron neutron capture therapy for clear cell sarcoma

Appl Radiat Isot. 2020 Dec:166:109324. doi: 10.1016/j.apradiso.2020.109324. Epub 2020 Aug 3.

Authors

Takuya Fujimoto¹, Minoru Suzuki², Tamotsu Sudo³, Ikuo Fujita⁴, Toshiko Sakuma⁵, Yoshinori Sakurai², Takanori Hirose⁵, Masayuki Morishita⁴, Takushi Takata², Yuki Tamari², Hiroki Tanaka², Tooru Andoh⁶, Teruya Kawamoto⁷, Hitomi Hara⁸, Naomasa Fukase⁸, Yohei Kawakami⁸, Rika Shigemoto⁴, Tomoyuki Matsumoto⁸, Hideki Ichikawa⁶, Koji Ono⁹, Ryosuke Kuroda⁸, Toshihiro Akisue¹⁰

Affiliations

¹ Department of Orthopaedic Surgery, Hyogo Cancer Center, 13-70 Kitaouji-cho, Akashi, 673-8558, Japan; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. Electronic address: fujitaku@hp.pref.hyogo.jp.
² Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2 Asashiro-Nishi, Kumatori-cho, Sennan-gun, 590-0494, Japan.
³ Section of Translational Research, Hyogo Cancer Center, 13-70 Kitaouji-cho, Akashi, 673-8558, Japan.
⁴ Department of Orthopaedic Surgery, Hyogo Cancer Center, 13-70 Kitaouji-cho, Akashi, 673-8558, Japan.
⁵ Department of Diagnostic Pathology, Hyogo Cancer Center, 13-70 Kitaouji-cho, Akashi, 673-8558, Japan.
⁶ Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, 650-8586, Japan.
⁷ Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan; Division of Orthopaedic Surgery, Kobe University International Clinical Cancer Research Center, 1-5-1 Minatojimaminami-cho, Chuo-ku, Kobe, 650-0047, Japan.
⁸ Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
⁹ Kansai BNCT Medical Center, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, 569-8686, Japan.
¹⁰ Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan; Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 7-10- 2 Tomogaoka, Suma-ku, Kobe, 654-0142, Japan.

PMID: 32861973
DOI: 10.1016/j.apradiso.2020.109324

Abstract

Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare, malignant tumor arising in lower extremities with no effective treatment other than wide surgical resection. Here described is a case of primary CCS in the peroneal tendon of the right foot of a 54-year-old woman enrolled to undergo BNCT. The tumor mass post-BNCT disappeared totally without damage to other normal tissue, demonstrating, for the first time, the potential efficacy of BNCT in complete local control of CCS.

Keywords: Boron neutron capture therapy (BNCT); CD98; Clear cell sarcoma of tendons and aponeuroses; Clinical treatment; L-type amino acid transporter 1 (LAT1); p-borono-l-phenylalanine (BPA).

Publication types

Case Reports

MeSH terms

Biopsy, Needle
Boron Neutron Capture Therapy / methods*
Female
Foot Diseases / diagnostic imaging
Foot Diseases / pathology
Foot Diseases / radiotherapy*
Humans
Lung Neoplasms / secondary
Magnetic Resonance Imaging
Middle Aged
Positron Emission Tomography Computed Tomography
Radiotherapy Planning, Computer-Assisted
Sarcoma, Clear Cell / diagnostic imaging
Sarcoma, Clear Cell / radiotherapy*
Sarcoma, Clear Cell / secondary
Tendons* / diagnostic imaging
Tendons* / pathology
Treatment Outcome