Abstract
Differentiation of human cytomegalovirus specific T cells is a slow process requiring years. In the acute phase, EM predominate; subsequently, no contraction occurs (memory inflation) and TEMRA increase, especially among CD8+ T cells, while few LTM T cells appear. After some years, LTM stabilizes and predominate among CD4+ .
Keywords:
T cells; human cytomegalovirus; memory T cells; memory inflation; primary infection.
© 2020 Wiley-VCH GmbH.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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CD4-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / immunology*
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Cell Differentiation / immunology
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Cytomegalovirus / immunology*
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Cytomegalovirus Infections / complications
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Cytomegalovirus Infections / immunology*
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Cytomegalovirus Infections / virology
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Female
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Follow-Up Studies
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Host Microbial Interactions / immunology
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Humans
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Immunocompetence
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Immunologic Memory*
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Middle Aged
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Pregnancy
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Pregnancy Complications, Infectious / immunology
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Pregnancy Complications, Infectious / virology
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Time Factors