Slow cytomegalovirus-specific CD4+ and CD8+ T-cell differentiation: 10-year follow-up of primary infection in a small number of immunocompetent hosts

Eur J Immunol. 2021 Jan;51(1):253-256. doi: 10.1002/eji.202048772. Epub 2020 Sep 25.

Abstract

Differentiation of human cytomegalovirus specific T cells is a slow process requiring years. In the acute phase, EM predominate; subsequently, no contraction occurs (memory inflation) and TEMRA increase, especially among CD8+ T cells, while few LTM T cells appear. After some years, LTM stabilizes and predominate among CD4+ .

Keywords: T cells; human cytomegalovirus; memory T cells; memory inflation; primary infection.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Cell Differentiation / immunology
  • Cytomegalovirus / immunology*
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / immunology*
  • Cytomegalovirus Infections / virology
  • Female
  • Follow-Up Studies
  • Host Microbial Interactions / immunology
  • Humans
  • Immunocompetence
  • Immunologic Memory*
  • Middle Aged
  • Pregnancy
  • Pregnancy Complications, Infectious / immunology
  • Pregnancy Complications, Infectious / virology
  • Time Factors