Gating and calcium-sensing mechanisms of TRPA1 channels revealed

Sebastian E Brauchi; Brad S Rothberg

doi:10.1016/j.ceca.2020.102278

Gating and calcium-sensing mechanisms of TRPA1 channels revealed

Cell Calcium. 2020 Nov:91:102278. doi: 10.1016/j.ceca.2020.102278. Epub 2020 Aug 20.

Authors

Sebastian E Brauchi¹, Brad S Rothberg²

Affiliations

¹ Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, and Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Valdivia, Chile. Electronic address: sbrauchi@uach.cl.
² Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA. Electronic address: rothberg@temple.edu.

Abstract

Novel structures of the human TRPA1 channel were determined in the presence of the agonist iodoacetamide and the antagonist A-967079, to reveal the open and closed states of the channel, respectively. The structures further revealed the location of Ca²⁺ modulatory site that is likely conserved among several TRP subgroups.

Keywords: Calcium; Channel; Mustard; Pain; Sensory; TRP.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Calcium / metabolism*
Humans
Ion Channel Gating*
Models, Molecular
TRPA1 Cation Channel / chemistry
TRPA1 Cation Channel / metabolism*

Substances

TRPA1 Cation Channel
Calcium

Grants and funding

R01 GM126581/GM/NIGMS NIH HHS/United States