Cytokine-directed therapy with tocilizumab for immune checkpoint inhibitor-related hemophagocytic lymphohistiocytosis

B C Özdemir; S Latifyan; M Perreau; C Fenwick; L Alberio; G Waeber; F Spertini; L de Leval; O Michielin; M Obeid

doi:10.1016/j.annonc.2020.08.2101

Cytokine-directed therapy with tocilizumab for immune checkpoint inhibitor-related hemophagocytic lymphohistiocytosis

Ann Oncol. 2020 Dec;31(12):1775-1778. doi: 10.1016/j.annonc.2020.08.2101. Epub 2020 Aug 25.

Authors

B C Özdemir¹, S Latifyan², M Perreau³, C Fenwick⁴, L Alberio⁵, G Waeber³, F Spertini³, L de Leval⁶, O Michielin⁷, M Obeid⁸

Affiliations

¹ Centre Hospitalier Universitaire Vaudois (CHUV), Service of Medical Oncology Department of Oncology, Lausanne, Switzerland; International Cancer Prevention Institute, Epalinges, Switzerland.
² Centre Hospitalier Universitaire Vaudois (CHUV), Service of Medical Oncology Department of Oncology, Lausanne, Switzerland.
³ Centre Hospitalier Universitaire Vaudois (CHUV), Service of Immunology and Allergy, Department of Medicine, Lausanne, Switzerland; University Hospital of Lausanne, Lausanne, Switzerland.
⁴ Centre Hospitalier Universitaire Vaudois (CHUV), Service of Immunology and Allergy, Department of Medicine, Lausanne, Switzerland.
⁵ University Hospital of Lausanne, Lausanne, Switzerland; Centre Hospitalier Universitaire Vaudois (CHUV), Service of Hematology Division, Department of Oncology and Central Hematology Laboratory, Department of Laboratory Medicine and Pathology, Lausanne, Switzerland.
⁶ University Hospital of Lausanne, Lausanne, Switzerland; Centre Hospitalier Universitaire Vaudois (CHUV), Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne, Switzerland.
⁷ Centre Hospitalier Universitaire Vaudois (CHUV), Service of Medical Oncology Department of Oncology, Lausanne, Switzerland; University Hospital of Lausanne, Lausanne, Switzerland.
⁸ Centre Hospitalier Universitaire Vaudois (CHUV), Service of Immunology and Allergy, Department of Medicine, Lausanne, Switzerland; University Hospital of Lausanne, Lausanne, Switzerland; Centre Hospitalier Universitaire Vaudois (CHUV), Vaccine and Immunotherapy Center, Lausanne, Switzerland. Electronic address: michel.obeid@chuv.ch.

PMID: 32858151
DOI: 10.1016/j.annonc.2020.08.2101

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal, Humanized / adverse effects
Cytokines
Humans
Immune Checkpoint Inhibitors*
Lymphohistiocytosis, Hemophagocytic* / drug therapy

Substances

Antibodies, Monoclonal, Humanized
Cytokines
Immune Checkpoint Inhibitors
tocilizumab