Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?

Hamdan Hamdan; Shahrukh K Hashmi; Hillard Lazarus; Robert Peter Gale; Wenchun Qu; Riad El Fakih

doi:10.1016/j.blre.2020.100742

Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?

Blood Rev. 2021 Mar:46:100742. doi: 10.1016/j.blre.2020.100742. Epub 2020 Aug 13.

Authors

Hamdan Hamdan¹, Shahrukh K Hashmi², Hillard Lazarus³, Robert Peter Gale⁴, Wenchun Qu⁵, Riad El Fakih⁶

Affiliations

¹ Department of Physiology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
² Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA; Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
³ Division of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, USA.
⁴ Haematology Research Centre, Imperial College London, London, UK.
⁵ Department of Pain Medicine, Mayo Clinic, Jacksonville, FL, USA; Center of Regenerative Medicine, Mayo Clinic, Jacksonville, FL, USA.
⁶ Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. Electronic address: relfakih1@kfshrc.edu.sa.

Abstract

Mesenchymal stromal cells (MSC) have immune regulatory and tissue regenerative properties. MSCs are being studied as a therapy option for many inflammatory and immune disorders and are approved to treat acute graft-versus-host disease (GvHD). The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic and associated coronavirus infectious disease-19 (COVID-19) has claimed many lives. Innovative therapies are needed. Preliminary data using MSCs in the setting of acute respiratory distress syndrome (ARDS) in COVID-19 are emerging. We review mechanisms of action of MSCs in inflammatory and immune conditions and discuss a potential role in persons with COVID-19.

Keywords: COVID-19; Mesenchymal stromal cell; SARS-CoV2.

Publication types

Review

MeSH terms

Animals
COVID-19 / therapy*
Humans
Mesenchymal Stem Cell Transplantation / methods*
Respiratory Distress Syndrome / therapy*
SARS-CoV-2 / isolation & purification