Diagnosis and management of tumor lysis syndrome

Isha Puri; Deep Sharma; Krishna S Gunturu; Andaleeb A Ahmed

doi:10.1080/20009666.2020.1761185

Diagnosis and management of tumor lysis syndrome

J Community Hosp Intern Med Perspect. 2020 Jun 14;10(3):269-272. doi: 10.1080/20009666.2020.1761185.

Authors

Isha Puri¹, Deep Sharma², Krishna S Gunturu³, Andaleeb A Ahmed⁴

Affiliations

¹ Department of Hospital Medicine, Lahey Hospital and Medical Center, Burlington, MA, USA.
² Department of Medicine (Nephrology), Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
³ Department of Hematology and Oncology, Lahey Hospital and Medical Center, Burlington, MA, USA.
⁴ Department of Anesthesiology and Perioperative Medicine, Tufts School of Medicine, Lahey Hospital and Medical Center, Burlington, MA, USA.

Abstract

Tumor lysis syndrome (TLS) is an oncological emergency characterized by a classic tetrad of hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. Risk assessment and prophylactic therapy is critical in preventing this oncological emergency. Treatment of established TLS involves aggressive hydration, electrolyte management, and the use of hypouricemic agents.

Keywords: Tumor lysis syndrome; cancer; malignancy; tumor; uric acid.

Publication types

Review