Association of Preoperative Neutrophil/Lymphocyte Ratio with Clinical Outcomes in Dedifferentiated Chondrosarcoma Patients

Chenglei Liu; Yue Xing; Qiong Jiao; Qingcheng Yang; Wenbin Yu; Yuncheng Li; Xiaofeng Tao; Weiwu Yao

doi:10.2147/CMAR.S266671

Association of Preoperative Neutrophil/Lymphocyte Ratio with Clinical Outcomes in Dedifferentiated Chondrosarcoma Patients

Cancer Manag Res. 2020 Aug 3:12:6719-6726. doi: 10.2147/CMAR.S266671. eCollection 2020.

Authors

Chenglei Liu^#¹, Yue Xing^#², Qiong Jiao³, Qingcheng Yang⁴, Wenbin Yu⁵, Yuncheng Li^#⁶, Xiaofeng Tao¹, Weiwu Yao⁷

Affiliations

¹ Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
² Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.
³ Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.
⁴ Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.
⁵ Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Head and Neck Surgery, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China.
⁶ Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
⁷ Department of Radiology, Shanghai Tongren Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.

^# Contributed equally.

Abstract

Background: Dedifferentiated chondrosarcoma (DC) is an extremely uncommon malignant bone tumor with dismal survival outcomes. The purpose of this study was to investigate whether the preoperative neutrophil/lymphocyte ratio (NLR) has the ability to predict overall survival (OS) in DC patients.

Materials and methods: Twenty-three DC patients with surgical resection were retrospectively reviewed between 2008 and 2015. The clinical pathological information and survival data were collected for analysis. The cut-off point for NLR was defined by receiver operating curve (ROC). The impact of NLR level on OS between two groups was compared using Kaplan-Meier curves with the Log-rank test. The association between NLR and OS was calculated by univariate and multivariate Cox proportional models.

Results: From the ROC analysis, the optimal NLR cut-off point was 3.11. Patients with high NLR had a worse OS than low NLR (p = 0.003, Log-rank test). In univariate analysis, a significant association was observed between high NLR and poor OS (Hazard ratio (HR) 4.62, 95% confidence interval (CI) 1.48-14.34, p = 0.008). After adjustment of co-variables, high NLR had more than 4 times the risk of mortality (HR 4.01, 95% CI 1.12-14.26, p = 0.032).

Conclusion: Preoperative NLR in peripheral blood is an easily accessible and cost-effective prognostic biomarker in DC patients. A prospective study with large sample size is warranted.

Keywords: dedifferentiated chondrosarcoma; neutrophil/lymphocyte ratio; outcome; prognostic factor.

Grants and funding

This study was sponsored by the National Natural Science Foundation of China (No. 81771790), and Shanghai Scientific Research Plan Project (No.16511101101).