Different outcomes for transplant-eligible newly diagnosed multiple myeloma patients in Latin America according to the public versus private management: a GELAMM study

Leuk Lymphoma. 2020 Dec;61(13):3112-3119. doi: 10.1080/10428194.2020.1804558. Epub 2020 Aug 26.

Abstract

The aim of this study was to describe clinical and survival characteristics of transplant-eligible multiple myeloma (MM) patients in Latin America (LA), with a special focus on differences between public and private healthcare facilities. We included 1293 patients diagnosed between 2010 and 2018. A great disparity in outcomes and survival between both groups was observed. Late diagnosis and low access to adequate frontline therapy and ASCT in public institutions probably explain these differences. Patients treated with novel drug induction protocols, followed by autologous stem cell transplantation (ASCT) and maintenance, have similar overall survival compared to that published internationally.

Keywords: Latin America; Multiple myeloma; autologous stem cell transplantation; proteasome inhibitor.

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Latin America / epidemiology
  • Multiple Myeloma* / diagnosis
  • Multiple Myeloma* / epidemiology
  • Multiple Myeloma* / therapy
  • Transplantation, Autologous
  • Treatment Outcome