An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development

Grace H Hwang; Rosalind A Segal

doi:10.1016/j.devcel.2020.07.021

An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development

Dev Cell. 2020 Aug 24;54(4):425-426. doi: 10.1016/j.devcel.2020.07.021.

Authors

Grace H Hwang¹, Rosalind A Segal²

Affiliations

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Rosalind_Segal@dfci.harvard.edu.

PMID: 32841591
DOI: 10.1016/j.devcel.2020.07.021

Abstract

Hallmark mutations in WNT and SHH medulloblastoma are usually distinct, but DDX3X is often mutated in both subgroups. In this issue of Developmental Cell, Patmore et al. identify Ddx3x as essential for hindbrain patterning, cell fate determination, and as a tumor suppressor gene that restricts cell lineage progression in tumorigenesis.

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MeSH terms

Carcinogenesis
Cerebellar Neoplasms*
DEAD-box RNA Helicases / genetics
DEAD-box RNA Helicases / metabolism
Humans
Medulloblastoma* / genetics
Mutation
Rhombencephalon / metabolism

Substances

DDX3X protein, human
DEAD-box RNA Helicases