Climate plays an essential role in the blood pressure (BP) regulation. BP seasonal fluctuations are often explained by meteorological factors, such as changes of outdoor temperature and etc. The 260 cases of BP monitoring of patients with uncomplicated hypertensive crisis were analyzed. We studied the daily fluctuations of climate data indicators reflected in 4-hour intervals. Data analysis was performed considering unmodifiable risk factors for hypertension: age and gender. In the young age group, the daily average SBP was 131, in the middle age group - 130.5, in the elderly group-136.3 mmHg., p=0.000. 4-hourly mean values of SBP were higher in the older group and their correlations with meteorological elements were more significant. A multi-dimensional regression model, which included temperature, atmospheric pressure, relative humidity and horizontal visibility had an r square of 25%. Comparison by gender showed that the daily average SBP was higher in women, but a statistically significant regression model couldn`t be obtained. The results showed the presence of greater sensitivity to climatic and meteorological fluctuations for individuals, aged ≥ 60.