Squamous Non-Small-Cell Lung Cancer Molecularly Reclassified as Transdifferentiated Prostate Cancer Due to Identification of TMPRSS2-ERG Translocation With SOX2 Amplification

JCO Oncol Pract. 2020 Oct;16(10):695-697. doi: 10.1200/OP.20.00575. Epub 2020 Aug 24.

Authors

Nadza Tokaca¹, Wanyuan Cui¹, Stephen Hazell², Andrew G Nicholson³, Nicholas Van As⁴, Sanjay Popat^{1

4}

Affiliations

¹ The Lung Unit, Royal Marsden Hospital, London, United Kingdom.
² Department of Histopathology, Royal Marsden Hospital, London, United Kingdom.
³ Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, and National Heart and Lung Institute, Imperial College, London, United Kingdom.
⁴ The Institute of Cancer Research, London, United Kingdom.

PMID: 32840422
DOI: 10.1200/OP.20.00575

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Non-Small-Cell Lung*
Carcinoma, Squamous Cell*
Humans
Lung Neoplasms* / genetics
Male
Oncogene Proteins, Fusion / genetics
Prostatic Neoplasms* / genetics
SOXB1 Transcription Factors / genetics
Serine Endopeptidases
Transcriptional Regulator ERG
Translocation, Genetic

Substances

ERG protein, human
Oncogene Proteins, Fusion
SOX2 protein, human
SOXB1 Transcription Factors
TMPRSS2-ERG fusion protein, human
Transcriptional Regulator ERG
Serine Endopeptidases
TMPRSS2 protein, human