iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2

Xiao-Yuan Mao; Wei-Lin Jin

doi:10.1021/acschemneuro.0c00512

iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2

ACS Chem Neurosci. 2020 Sep 2;11(17):2489-2491. doi: 10.1021/acschemneuro.0c00512. Epub 2020 Aug 25.

Authors

Xiao-Yuan Mao^{1

2

3

4}, Wei-Lin Jin^{5

6}

Affiliations

¹ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P. R. China.
² Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 110 Xiangya Road, Changsha 410078, P. R. China.
³ Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China.
⁴ National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, Hunan 410008, P. R. China.
⁵ Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
⁶ National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

PMID: 32840109
DOI: 10.1021/acschemneuro.0c00512

Abstract

Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a severe public health problem with a high rate of morbidity and mortality. A mounting number of clinical investigations illustrate that COVID-19 patients suffer from neurologic conditions in addition to respiratory symptoms. In a recent article, Yuen and colleagues present the first experimental evidence of SARS-CoV-2 infection in the human central nervous system using induced pluripotent stem cells (iPSCs)-derived platform including human neural progenitor cells, neurospheres, and three-dimensional brain organoids (Yuen, K.Y., and Huang, J.D. et al. (2020) Cell Res. DOI: 10.1038/s41422-020-0390-x).

Keywords: SARS-CoV-2; brain infection; human neural progenitor cell; iPSCs; neurosphere; organoid.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Betacoronavirus*
Brain / pathology*
Brain / virology
COVID-19
Coronavirus Infections / pathology*
Coronavirus Infections / transmission*
Feasibility Studies
Humans
Induced Pluripotent Stem Cells / pathology*
Induced Pluripotent Stem Cells / virology
Organoids / pathology
Organoids / virology
Pandemics
Pneumonia, Viral / pathology*
Pneumonia, Viral / transmission*
SARS-CoV-2