NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Yuling Xu; Yi Zhang; Jun Li; Jusung An; Chonglu Li; Suya Bai; Amit Sharma; Ganzhen Deng; Jong Seung Kim; Yao Sun

doi:10.1016/j.biomaterials.2020.120315

NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Biomaterials. 2020 Nov:259:120315. doi: 10.1016/j.biomaterials.2020.120315. Epub 2020 Aug 15.

Authors

Yuling Xu¹, Yi Zhang², Jun Li³, Jusung An⁴, Chonglu Li¹, Suya Bai², Amit Sharma⁵, Ganzhen Deng¹, Jong Seung Kim⁶, Yao Sun⁷

Affiliations

¹ State Key Laboratory of Agricultural Microbiology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
² Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Center of Chemical Biology, College of Chemistry, Central China Normal University, Wuhan, 430079, China.
³ Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan, 430070, China.
⁴ Department of Chemistry, Korea University, Seoul, 02841, South Korea.
⁵ Biomedical Instrumentation, CSIR-Central Scientific Instruments Organization, Sector-30C, Chandigarh, 160030, India.
⁶ Department of Chemistry, Korea University, Seoul, 02841, South Korea. Electronic address: jongskim@korea.ac.kr.
⁷ State Key Laboratory of Agricultural Microbiology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address: sunyaogbasp@126.com.

PMID: 32836057
DOI: 10.1016/j.biomaterials.2020.120315

Abstract

Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.

Keywords: Aggregation-induced emission; Organic dye; Photodynamic therapy; Photothermal therapy; The second infrared channel.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Lasers
Mice
Nanoparticles*
Neoplasms* / drug therapy
Photochemotherapy*
Phototherapy
Photothermal Therapy
Staphylococcus aureus