5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses

Y V Nikolayeva; E A Ulashchik; E V Chekerda; A V Galochkina; N A Slesarchuk; A A Chistov; T D Nikitin; V A Korshun; V V Shmanai; A V Ustinov; A A Shtro

doi:10.1134/S1068162020030139

5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses

Russ J Bioorg Chem. 2020;46(3):315-320. doi: 10.1134/S1068162020030139. Epub 2020 Jun 20.

Authors

Y V Nikolayeva¹, E A Ulashchik², E V Chekerda¹, A V Galochkina¹, N A Slesarchuk^{3

4

5}, A A Chistov^{3

5}, T D Nikitin^{3

4}, V A Korshun^{3

5

6}, V V Shmanai², A V Ustinov^{3

5}, A A Shtro¹

Affiliations

¹ Smorodintsev Research Institute of Influenza, 197376 St. Petersburg, Russia.
² Institute of Physical Organic Chemistry of the NAS Belarus, 220072 Minsk, Belarus.
³ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
⁴ Department of Chemistry, Moscow State University, 119991 Moscow, Russia.
⁵ Department of Biology and Biotechnology, National Research University Higher School of Economics, 117312 Moscow, Russia.
⁶ Gause Institute of New Antibiotics, 119021 Moscow, Russia.

Abstract

In this work, we describe the synthesis of 5-(perylen-3-ylethynyl)uridine and its ability to effectively inhibit the replication of respiratory disease pathogens in cell culture, namely: influenza A virus (IVA); type 3 parainfluenza virus (PIV-3); and human respiratory syncytial virus (RSV). Related known compounds were also analyzed: 5-(perylen-3-ylethynyl)-2'-deoxy-uridine; 5-(perylen-3-ylethynyl)-arabino-uridine; and 1-carboxymethyl-3-pivaloyloxymethyl-5-(perylen-3-ylethynyl)uracil.

Keywords: antiviral activity; influenza A virus; non-nucleoside derivatives; nucleosides; perylenylethynyluracil compounds; respiratory viruses.