ACE2 plays a critical role in SARS-CoV-2 infection to cause COVID-19 and SARS-CoV-2 spike protein binds to ACE2 and probably functionally inhibits ACE2 to aggravate the underlying diseases of COVID-19. The important factors that affect the severity and fatality of COVID-19 include patients' underlying diseases and ages. Therefore, particular care to the patients with underlying diseases is needed during the treatment of COVID-19 patients.
Keywords: ACE2, Angiotensin converting enzyme 2; ACEI, ACE inhibitor; Angiotensin converting enzyme 2; COVID-19, Coronavirus Infectious Disease-19; CVD, cardiovascular disease; Coronavirus Infectious Disease-19; Health disparity; PAH, pulmonary artery hypertension; R0, Reproductive number; RAS, Renin-angiotensin system; RBD, Receptor binding domain; S, Spike: TMPRSS2, Transmembrane protease, serine 2; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus −2 SARS-CoV-2, Middle East Respiratory Syndrome 2: MERS-2; SNP, Single Nucleotide Polymorphism; Severe Acute Respiratory Syndrome Coronavirus −2; Single Nucleotide Polymorphism; Underlying diseases.
© 2020 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.