Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Pengfan Li; Kanjun Chen; Zheng Mao; Yue Luo; Yan Xue; Yuli Zhang; Xueying Wang; Lihang Zhang; Sizhen Gu; Danbo Dou

doi:10.1155/2020/7305241

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Gastroenterol Res Pract. 2020 Aug 3:2020:7305241. doi: 10.1155/2020/7305241. eCollection 2020.

Authors

Pengfan Li¹, Kanjun Chen¹, Zheng Mao², Yue Luo³, Yan Xue⁴, Yuli Zhang¹, Xueying Wang¹, Lihang Zhang¹, Sizhen Gu¹, Danbo Dou¹

Affiliations

¹ Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
² Department of Foreign Language Teaching Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
³ Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
⁴ Institute of Tramotology and Orthopedics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Abstract

Methods: MEDLINE, Embase, and CENTRAL were systematically searched for correlative studies till 2 November 2019. RevMan5.3 was used to estimate relevance.

Results: Three studies with 166008 participants were included. The risk of pancreatitis significantly increased in the patients with CD (OR, 3.40; 95% CI, 2.70-4.28; P < 0.00001) and UC (OR, 2.49; 95% CI, 1.91-3.26; P < 0.00001). Increased risks of CD (OR, 12.90; 95% CI, 5.15-32.50; P < 0.00001) and UC (OR, 2.80; 95% CI, 1.00-7.86; P = 0.05) were found in patients with chronic pancreatitis. As for patients with acute pancreatitis, there were significant association of CD (OR, 3.70; 95% CI, 1.90-7.60; P = 0.0002), but were not UC.

Conclusions: The evidence confirmed an association between pancreatitis and IBD. When pancreatitis patients have chronic diarrhea and mucus blood stool or IBD patients have repeated abdominal pain and weight loss, they should consult pancreatic and gastrointestinal specialists.

Publication types

Review