HMGB1 in inflammation and cancer

J Hematol Oncol. 2020 Aug 24;13(1):116. doi: 10.1186/s13045-020-00950-x.

Abstract

High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune response, and participate in the regulation of inflammation and cancer progression.

Keywords: Cancer; DAMP; HMGB1; Inflammation; RAGE; TLR.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / physiology
  • Autophagy / physiology
  • Carcinogenesis
  • Cell Nucleus / metabolism
  • Cell Survival / physiology
  • Chemoradiotherapy
  • Cytokines / metabolism
  • Cytoplasm / metabolism
  • DNA Repair
  • HMGB1 Protein / physiology*
  • Humans
  • Immunity / physiology
  • Immunotherapy
  • Inflammation / metabolism*
  • Neoplasm Proteins / physiology*
  • Neoplasms / metabolism*
  • Neoplasms / therapy

Substances

  • Cytokines
  • HMGB1 Protein
  • HMGB1 protein, human
  • Neoplasm Proteins