Paradigm shift on the era of next generation sequencing(NGS): NGS completely changed the volume and acquiring speed of the genetic information. Secondary findings obtained by cancer profiling genomic testing should be handled by cooperation of genetic medicine and cancer medicine. Recommendations of the Communication Process on Genomic Medicine was announced for clinical sequencing using Next Generation Sequencer by Japan Agency for Medical Research and Development( AMED)Research Team. Secondary findings to be disclosed are listed up by American College of Medical Genetics and Genomics. Actionability of these 59 genes to be re-accessed on the conditions in Japan.