The role of depressive symptoms within the association of long-term exposure to indoor and outdoor traffic noise and cognitive function - Results from the Heinz Nixdorf Recall study

Lilian Tzivian; Vanessa Soppa; Angela Winkler; Frauke Hennig; Christian Weimar; Susanne Moebus; Barbara Hoffmann; Martha Jokisch; Heinz Nixdorf Recall study group

doi:10.1016/j.ijheh.2020.113570

The role of depressive symptoms within the association of long-term exposure to indoor and outdoor traffic noise and cognitive function - Results from the Heinz Nixdorf Recall study

Int J Hyg Environ Health. 2020 Sep:230:113570. doi: 10.1016/j.ijheh.2020.113570. Epub 2020 Aug 18.

Authors

Lilian Tzivian¹, Vanessa Soppa², Angela Winkler³, Frauke Hennig², Christian Weimar³, Susanne Moebus⁴, Barbara Hoffmann², Martha Jokisch³; Heinz Nixdorf Recall study group

Affiliations

¹ Faculty of Medicine, University of Latvia, Riga, Latvia; Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University Hospital of Düsseldorf, Germany. Electronic address: Liliana.Civjane@lu.lv.
² Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University Hospital of Düsseldorf, Germany.
³ Department of Neurology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
⁴ Centre for Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.

PMID: 32823068
DOI: 10.1016/j.ijheh.2020.113570

Abstract

Objectives: Traffic noise is negatively associated with cognitive function, and its perception can differ between depressed and non-depressed people. We studied the role of depressive symptoms in the association between traffic noise and cognitive function. We studied the role of depressive symptoms in the association between traffic noise and cognitive function.

Methods: During the first follow-up examination (2006-2008) of the German Heinz Nixdorf Recall study, cognitive function (five subtests and an additive global summary score, GCS) and depressive symptoms (CES-D score) were assessed in 2745 participants (aged 50-80, 49.8% women). Mild cognitive impairment (MCI) was diagnosed according to the Petersen criteria in 380 participants. Long-term exposure to traffic noise was modeled as weighted 24-h mean (L_DEN) and night-time mean (L_NIGHT) at the façade of the baseline addresses, and was corrected for indoors (L_{DEN_IN} and L_{NIGHT_IN}). We developed multiple linear and logistic regression models adjusted for individual-level characteristics to investigate cross-sectionally the role of depressive symptoms in the association of traffic noise with cognitive function.

Results: Overall, 8.6% participants had depressive symptoms. The median noise values were L_DEN 52.1 dB(A) and L_{DEN_IN} 34.7 dB(A). Associations were slightly stronger for cognitive subtests in those with severe depression (CES-D>21), i.e., per 10 dB(A) L_DEN and verbal fluency: β = -0.04 [-0.11; 0.03] for CES-D≤21 and β = -0.09 [-0.24; -0.06] for CES-D>21. Additional adjustment of the main model for CES-D did not change the association between noise and cognitive outcomes. Estimates using indoor noise exposure were generally stronger and more precise.

Conclusions: Depressed people may be more susceptible to adverse effects of noise than non-depressed. Modeled estimates of indoor noise exposure is possibly a more appropriate measure of exposure.

Keywords: Cognitive function; Depressive symptoms; Indoor noise; Long-term exposure; Outdoor noise; Road traffic noise.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cognition
Cognitive Dysfunction* / etiology
Depression
Environmental Exposure
Female
Humans
Male
Noise, Transportation* / adverse effects