Review: Remotely controlled magneto-regulation of therapeutics from magnetoelastic gel matrices

Sayan Ganguly; Shlomo Margel

doi:10.1016/j.biotechadv.2020.107611

Review: Remotely controlled magneto-regulation of therapeutics from magnetoelastic gel matrices

Biotechnol Adv. 2020 Nov 15:44:107611. doi: 10.1016/j.biotechadv.2020.107611. Epub 2020 Aug 18.

Authors

Sayan Ganguly¹, Shlomo Margel²

Affiliations

¹ The Institute of Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
² The Institute of Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel. Electronic address: shlomo.margel@mail.biu.ac.il.

PMID: 32818552
DOI: 10.1016/j.biotechadv.2020.107611

Abstract

Surface active magnetic nanoparticles especially superparamagnetic iron oxides are already occupying a major domain in medical therapeutics. Arresting of these magnetic nanoparticles into polymer hydrogel is a spatial assembly of nanoparticles that serves the precise delivery of drug molecules. Magnetic hydrogels are very less cultured area still in the biomedical field. This review embraces how the external magnetic field (either static or oscillating) affects the payload release from the hydrogel matrix and their magneto-regulative deformation. Besides these, we also discussed how the ferrosponge and biphasic ferrogel based scaffold type systems impact over the release kinetics and tunability of drug release behaviours.

Keywords: Biphasic; Drug release; Ferrosponge; Magneto-regulative deformation; Medical therapeutics; Polymer hydrogel; Superparamagnetic.

Publication types

Review

MeSH terms

Drug Delivery Systems*
Hydrogels
Magnetics
Nanoparticles*
Polymers

Substances

Hydrogels
Polymers