Myocardial Inflammatory Changes Before and After Antiretroviral Therapy Initiation in People With Advanced Human Immunodeficiency Virus Disease

Open Forum Infect Dis. 2020 Jul 28;7(8):ofaa297. doi: 10.1093/ofid/ofaa297. eCollection 2020 Aug.

Abstract

Because of the high frequency of late presentation of human immunodeficiency virus (HIV) disease in our population, we decided to explore the presence of myocarditis among people with HIV infection and advanced immunosuppression (less than 200 CD4+ cells/μL) and to describe the inflammatory changes observed after combined antiretroviral therapy initiation in an observational, longitudinal, prospective cohort. We performed both cardiovascular magnetic resonance imaging and doppler transthoracic echocardiogram.

Keywords: HIV-associated myocarditis; IRIS; antiretroviral therapy; myocarditis.