Concerns of Hereditary Breast Cancer in Pregnancy and Lactation

Jennifer Chen; Vishnu Prasath; Jennifer Axilbund; Mehran Habibi

doi:10.1007/978-3-030-41596-9_17

Concerns of Hereditary Breast Cancer in Pregnancy and Lactation

Adv Exp Med Biol. 2020:1252:129-132. doi: 10.1007/978-3-030-41596-9_17.

Authors

Jennifer Chen¹, Vishnu Prasath¹, Jennifer Axilbund¹, Mehran Habibi²

Affiliations

¹ Department of Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
² Department of Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. mhabibi2@jhmi.edu.

PMID: 32816272
DOI: 10.1007/978-3-030-41596-9_17

Abstract

Genetic testing should be offered to all women less than 40 years of age who are diagnosed with breast cancer, and patients with PABC are generally among them. However, there is no specific study about these cases, and whether genetic testing should be carried out during or after pregnancy is not known. Generally, testing before delivery should only be performed if positive results change management plans, such as undergoing fetal testing and choosing mastectomy instead of breast conserving surgery.

Keywords: Breast cancer in pregnancy; Genetic mutations; Genetic testing; Prenatal screening; Prognosis; Tumor suppressor genes.

Publication types

Review

MeSH terms

Adult
Breast Neoplasms / diagnosis
Breast Neoplasms / genetics*
Female
Genetic Testing*
Humans
Lactation*
Mastectomy
Pregnancy
Pregnancy Complications, Neoplastic / diagnosis
Pregnancy Complications, Neoplastic / genetics*
Prenatal Diagnosis