Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus

Biochem J. 2020 Aug 28;477(16):2967-2970. doi: 10.1042/BCJ20200286.

Abstract

Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron acquisition. However, in the current study, neither growth assays on solid and in liquid media, analysis of siderophore production nor expression analysis of genes involved in iron acquisition indicated the involvement of Mac1 in the regulation of iron uptake in A. fumigatus.

Keywords: copper; gene expression and regulation; iron; mycology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus fumigatus / drug effects
  • Aspergillus fumigatus / genetics
  • Aspergillus fumigatus / growth & development
  • Aspergillus fumigatus / metabolism*
  • Copper / pharmacology*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Gene Expression Regulation, Fungal / drug effects*
  • Iron / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Virulence

Substances

  • Fungal Proteins
  • Transcription Factors
  • Copper
  • Iron