FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction

Jinghui Lei; Si Wang; Wang Kang; Qun Chu; Zunpeng Liu; Liang Sun; Yun Ji; Concepcion Rodriguez Esteban; Yan Yao; Juan Carlos Izpisua Belmonte; Piu Chan; Guang-Hui Liu; Weiqi Zhang; Moshi Song; Jing Qu

doi:10.1007/s13238-020-00779-7

FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction

Protein Cell. 2021 Feb;12(2):145-151. doi: 10.1007/s13238-020-00779-7.

Authors

Jinghui Lei^#¹, Si Wang^#^{1

2

3}, Wang Kang^#^{4

5}, Qun Chu⁶, Zunpeng Liu^{6

5}, Liang Sun⁷, Yun Ji^{2

3

5}, Concepcion Rodriguez Esteban⁸, Yan Yao⁹, Juan Carlos Izpisua Belmonte⁸, Piu Chan¹, Guang-Hui Liu^{10

11

12

13}, Weiqi Zhang^{14

15

16}, Moshi Song^{17

18

19}, Jing Qu^{20

21

22}

Affiliations

¹ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
² State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
³ Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
⁴ Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
⁵ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁶ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
⁷ The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, 100730, China.
⁸ Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, 92037, USA.
⁹ Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
¹⁰ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.
¹¹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹² Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹³ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
¹⁴ Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. zhangwq@big.ac.cn.
¹⁵ Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangwq@big.ac.cn.
¹⁶ University of Chinese Academy of Sciences, Beijing, 100049, China. zhangwq@big.ac.cn.
¹⁷ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
¹⁸ Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
¹⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.
²⁰ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
²¹ Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
²² University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Engineering*
Disease Models, Animal
Forkhead Box Protein O3 / genetics
Forkhead Box Protein O3 / metabolism*
Heterografts
Humans
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells / metabolism*
Mice
Myocardial Infarction / genetics
Myocardial Infarction / metabolism
Myocardial Infarction / therapy*
Myocardium / metabolism*

Substances

FOXO3 protein, human
Forkhead Box Protein O3