LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase

Circ Res. 2020 Sep 25;127(8):1112-1114. doi: 10.1161/CIRCRESAHA.120.317128. Epub 2020 Aug 17.
No abstract available

Keywords: angiopoietins; cholesterol; lipoproteins; metabolism; triglycerides.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiopoietin-Like Protein 3
  • Angiopoietin-like Proteins / genetics*
  • Angiopoietin-like Proteins / metabolism
  • Animals
  • Biomarkers / blood
  • Cholesterol, LDL / blood*
  • Disease Models, Animal
  • Down-Regulation
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / genetics
  • Hypercholesterolemia / therapy*
  • Lipase / genetics
  • Lipase / metabolism*
  • Liver / metabolism
  • Mice, Knockout
  • RNA Interference
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • RNAi Therapeutics*
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism

Substances

  • Angiopoietin-Like Protein 3
  • Angiopoietin-like Proteins
  • Angptl3 protein, mouse
  • Biomarkers
  • Cholesterol, LDL
  • RNA, Small Interfering
  • Receptors, LDL
  • Lipase
  • Lipg protein, mouse