Abstract
A novel family of four potent antimalarial macrolides, strasseriolides A-D (1-4), has been isolated from cultures of Strasseria geniculata CF-247251, a fungal strain obtained from plant tissues. The structures of these compounds, including their absolute configurations, were elucidated by HRMS, NMR spectroscopy, and X-ray single-crystal diffraction. The four compounds gave respective IC50 values of 9.810, 0.013, 0.123, and 0.128 μM against Plasmodium falciparum 3D7 parasites with no significant cytotoxicity against the HepG2 cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antimalarials / chemistry
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Ascomycota
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Fungi
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Macrolides / chemistry
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Macrolides / isolation & purification
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Macrolides / pharmacology*
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Molecular Structure
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Protein Synthesis Inhibitors / analysis*
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Protein Synthesis Inhibitors / chemistry
Substances
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Anti-Bacterial Agents
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Antimalarials
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Macrolides
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Protein Synthesis Inhibitors