The different faces of the NLRP3 inflammasome in cutaneous Leishmaniasis: A review

Ayyoub Kihel; Ikram Hammi; Dounia Darif; Meryem Lemrani; Myriam Riyad; Fadila Guessous; Khadija Akarid

doi:10.1016/j.cyto.2020.155248

The different faces of the NLRP3 inflammasome in cutaneous Leishmaniasis: A review

Cytokine. 2021 Nov:147:155248. doi: 10.1016/j.cyto.2020.155248. Epub 2020 Aug 15.

Authors

Ayyoub Kihel¹, Ikram Hammi¹, Dounia Darif¹, Meryem Lemrani², Myriam Riyad³, Fadila Guessous⁴, Khadija Akarid⁵

Affiliations

¹ Molecular Genetics and Immunophysiopathology Research Team, Health and Environment Laboratory, Aïn Chock Faculty of Sciences, Hassan II University of Casablanca (UH2C), Morocco.
² Laboratory of Parasitology and Vector-Borne-Diseases, Institut Pasteur du Maroc, Casablanca, Morocco.
³ Immunopathology of Infectious and Systemic Diseases, Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, UH2C, Morocco.
⁴ Department of Biological Sciences, Faculty of Medicine, Mohammed VI University of Health Sciences, Casablanca, Morocco.
⁵ Molecular Genetics and Immunophysiopathology Research Team, Health and Environment Laboratory, Aïn Chock Faculty of Sciences, Hassan II University of Casablanca (UH2C), Morocco. Electronic address: kakarid@yahoo.fr.

PMID: 32807586
DOI: 10.1016/j.cyto.2020.155248

Abstract

Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by Protozoa of the genus Leishmania. Clinical manifestations of this disease are the result of a complex interplay of diverse factors, including the genetic background and the immune status of the host. Understanding the impact of these factors on the CL pathology may provide new targets to manage the infection and improve clinical outcome. The NLRP3 inflammasome, an innate immune complex of several cell types, seems to be involved in the CL physiopathology. Current studies of its role show contradictory effects of this complex on the evolution of Leishmania infection in mice and humans. In this review, we discuss the data regarding different roles of the NLRP3 inflammasome in murine and human CL.

Keywords: Cutaneous leishmaniasis; Human CL; IL-18; IL-1β; Murine CL; NLRP3 inflammasome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Inflammasomes / metabolism*
Leishmania / pathogenicity
Leishmaniasis, Cutaneous / metabolism*
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein