Water-soluble oligofluorenes bearing N1-alkylcytosine side chains as turn-on and turn-off materials in telomere DNA length sensing

Chem Commun (Camb). 2020 Sep 17;56(74):10914-10917. doi: 10.1039/d0cc05153e.

Abstract

Water-soluble cationic and anionic oligofluorenes bearing N1-alkylcytosine side chains, namely OF-1 and OF-2, were synthesized. The photoluminescence (PL) intensity of an aqueous solution of OF-1 decreased on the addition of (TTAGGG)m as telomere DNA models. In contrast, the PL intensity of OF-2 increased on the addition of DNA.

MeSH terms

  • Cytosine / analogs & derivatives
  • Cytosine / chemistry*
  • DNA / chemistry*
  • Fluorenes / chemical synthesis
  • Fluorenes / chemistry*
  • Molecular Structure
  • Solubility
  • Telomere / chemistry*
  • Water / chemistry

Substances

  • Fluorenes
  • Water
  • Cytosine
  • DNA