ApoB48-Lipoproteins Are Associated with Cardiometabolic Risk in Adolescents with and without Polycystic Ovary Syndrome

Donna F Vine; Lawrence J Beilin; Sally Burrows; Rae-Chi Huang; Martha Hickey; Roger Hart; Spencer D Proctor; Trevor A Mori

doi:10.1210/jendso/bvaa061

ApoB48-Lipoproteins Are Associated with Cardiometabolic Risk in Adolescents with and without Polycystic Ovary Syndrome

J Endocr Soc. 2020 May 26;4(8):bvaa061. doi: 10.1210/jendso/bvaa061. eCollection 2020 Aug 1.

Authors

Donna F Vine¹, Lawrence J Beilin², Sally Burrows², Rae-Chi Huang³, Martha Hickey⁴, Roger Hart², Spencer D Proctor¹, Trevor A Mori²

Affiliations

¹ Metabolic and Cardiovascular Disease Laboratory, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
² Medical School, University of Western Australia, Royal Perth Hospital Unit, Perth, Australia.
³ The Telethon Kids Institute, University of Western Australia, Perth, Australia.
⁴ Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Victoria, Australia.

Abstract

Context: Adolescents with polycystic ovary syndrome (PCOS) have increased incidence of cardiometabolic risk factors including dyslipidemia. Atherogenic apolipoprotein (apo) B-lipoprotein remnants are associated with increased cardiovascular disease (CVD) risk.

Objective: The aim of this study was to determine the concentrations of fasting plasma apoB-lipoprotein remnants, apoB48 and apoB100, and their association with cardiometabolic risk factors and androgen indices in adolescent girls with and without PCOS.

Design setting and participants: Participants (n = 184) aged 17 years were recruited in the Menstruation in Teenagers Study from the Western Australian Pregnancy Cohort (Raine) Study.

The main outcome measures: Fasting plasma apo-B48 and -B100 lipoprotein remnant concentrations in adolescent girls with and without PCOS.

Results: Fasting plasma apoB48-lipoprotein remnants but not apoB100-lipoprotein remnants were elevated in adolescent girls with increased cardiometabolic risk compared with those with lower cardiometabolic risk (13.91 ± 5.06 vs 12.09 ± 4.47 µg/mL, P < .01). ApoB48-lipoprotein remnants were positively correlated with fasting plasma triglycerides (b = .43, P < .0001). The prevalence of increased cardiometabolic risk factors was 2-fold higher in those diagnosed with PCOS (35.3%) than in those without PCOS (16.3%).Conclusion: Adolescents with PCOS have a 2-fold higher incidence of cardiometabolic risk factors than those without PCOS. Fasting apoB48-lipoprotein remnants are elevated in adolescent girls with a high prevalence of cardiometabolic risk factors.

Keywords: ApoB-lipoprotein remnants; adiposity; adolescence; atherosclerosis; cardiometabolic risk factors; metabolic syndrome; polycystic ovary syndrome.