Evaluation of a Novel Quality of Life Scale for Schoolchildren with Nonstrabismic Binocular Vision Anomalies

Abstract

Background: The professional Quality of Life Scale (QLS) can provide a valuable reference for the diagnosis of visual function anomalies. In the present study, we aimed to design a novel QLS to specially quantify the life quality of schoolchildren with nonstrabismic binocular vision anomalies (NSBVAs) in China.

Methods: The novel QLS, named QOL-CVF20, was established based on classical vision-related scales and the administration of the questionnaire to 116 schoolchildren with NSBVAs and 100 healthy schoolchildren in China. The diagnostic reference value between QOL-CVF20 and VF-14 was evaluated on the questionnaires to 240 schoolchildren with NSBVAs and 238 healthy schoolchildren.

Results: All the subjects could complete the QOL-CVF20 questionnaires independently. QOL-CVF20 had good structural validity, content validity, and discriminant validity, when it was applied in Chinese schoolchildren. The average score of the NSBVA group was significantly lower than that of the control group (49.0 ± 6.9 vs. 69.7 ± 6.7, respectively; P < 0.01). Moreover, the average score of cured NSBVA schoolchildren after treatment (61.8 ± 22.6) was significantly improved (P < 0.01). Receiver operating characteristic curve analysis showed that QOL-CVF20 reflected strong separation between the NSBVA and healthy groups (AUC = 0.901). Meanwhile, QOL-CVF20 could detect individuals with NSBVAs with specificity of 0.847 and sensitivity of 0.846. The critical value of 58.50 in QOL-CVF20 could be effectively applied for quality of life assessment in schoolchildren with NSBVAs.

Conclusions: QOL-CVF20 could quantify the life quality of schoolchildren with NSBVAs and might be served as a valuable reference for early diagnosis and clinical evaluation of NSBVAs.