β-Casomorphin: A complete health perspective

Food Chem. 2021 Feb 1:337:127765. doi: 10.1016/j.foodchem.2020.127765. Epub 2020 Aug 5.

Abstract

β-Casomorphin-7 (BCM-7) is a heptapeptide dietary molecule derived from the digestion of the β-casein of dairy and dairy products. In this review, we have covered the extensive details about BCM and its derived peptides out of the gastrointestinal and enzymatic digestion of milk and milk products, its structure and properties, and its immunological aspects related to human health among infants and adults of both genders. We have left judgment about BCM's pros and cons to the reader by describing the details in a cyclopedic perspective. In addition, a section on the possible ways to detect BCMs from their sources using proteomics, genome-based techniques, such as PCR and aptamers, and other analytical techniques equip the reader to get an idea about the details of the diagnostics available and possible applications in future. Overall, this review will provide information to the end-users of milk and milk products to enable them to make their own decisions about BCMs.

Keywords: Dairy products; Health implications; Milk; β-Casomorphin-7.

Publication types

  • Review

MeSH terms

  • Animals
  • Autistic Disorder / pathology
  • Caseins / chemistry
  • Caseins / metabolism
  • Endorphins / blood
  • Endorphins / chemistry*
  • Endorphins / pharmacology
  • Humans
  • Immunity, Innate / drug effects
  • Milk / chemistry
  • Milk / metabolism
  • Neurites / drug effects
  • Neurites / metabolism
  • Peptide Fragments / blood
  • Peptide Fragments / chemistry
  • Peptide Fragments / pharmacology
  • T-Lymphocytes / cytology
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / metabolism

Substances

  • Caseins
  • Endorphins
  • Peptide Fragments
  • beta-casomorphin 7
  • beta-casomorphins