Objective: To investigate the influence of iron deficiency on the index of thalassemia screening.
Methods: 876 blood samples of the couples at childbearing age, who underwent red blood cell analysis, hemoglobin electrophoresis, ferritin and gene diagnosis were selected. The samples were divided into normal, iron deficiency, αthalassemia, α-thalassemia combining with iron deficiency, β-thalassemia and β-thalassemia combining with iron deficiency group. The differences of hematology index and hemolobin value A2 between each groups were analyzed.
Results: The value of Hb, MCV, MCH, MCHC in iron deficiency, αthalassemia, α-thalassemia combining with iron deficiency, β-thalassemia and β-thalassemia combining with iron deficiency group all were lower than that of normal group, while the value of RDW-CV was higher, in which the difference between β-thalassemia was the highest. The distribution of HbA2 among each groups was not significantly different expect of β-thalassemia. There was no significant correlation between HbA2 and ferritin level.
Conclusion: RDW-CV increases in both iron deficiency and thalassemia. Iron deficiency has no significant effect on the level of hemoglobin A2.
题目: 铁缺乏对地中海贫血筛查指标的影响.
目的: 探讨铁缺乏对地中海贫血筛查指标的影响.
方法: 选取我院同时进行血分析、血红蛋白电泳、血清铁蛋白检测和地中海贫血基因诊断的育龄期夫妇血液样本876份，分为正常组、铁缺乏组、α-地中海贫血组、α-地中海贫血合并铁缺乏组、β-地中海贫血组、β-地中海贫血合并铁缺乏组，统计分析各组血液学指标和血红蛋白A2（HbA2）水平差异.
结果: 铁缺乏组、α-地中海贫血组、β-地中海贫血组和地中海贫血合并铁缺乏组血液学指标Hb、MCV、MCH、MCHC均明显低于正常组（P＜0.05），RDW-CV均明显高于正常值（P＜0.05），其中，β-地中海贫血差异最明显。除β-地中海贫血外其余各组间HbA2结果及分布无明显差异，HbA2与铁蛋白水平无明显相关.
结论: RDW-CV在铁缺乏和地中海贫血时均可升高。铁缺乏对血红蛋白电泳HbA2结果无明显影响.