Implication and Inhibition Boolean Logic Gates Mimicked with Enzyme Reactions

Chemphyschem. 2020 Oct 2;21(19):2150-2154. doi: 10.1002/cphc.202000653. Epub 2020 Sep 10.

Abstract

The enzyme system mimicking Implication (IMPLY) and Inhibition (INHIB) Boolean logic gates has been designed. The same enzyme system was used to operate as the IMPLY or INHIB gate simply by reformulating the input signals. The optical analysis of the logic operation confirmed the output generation as expected for the studied logic gates. The conceptual approach to the IMPLY and INHIB logic gates allows their construction with many other enzymes operating in a similar way.

Keywords: Boolean logic; enzyme logic; implementation gate; inhibition gate; unconventional computing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus niger / enzymology
  • Biocatalysis
  • Enzyme Inhibitors / pharmacology*
  • Glucose Oxidase / antagonists & inhibitors*
  • Glucose Oxidase / metabolism
  • Hexokinase / antagonists & inhibitors*
  • Hexokinase / metabolism
  • Horseradish Peroxidase / antagonists & inhibitors*
  • Horseradish Peroxidase / metabolism
  • Mixed Function Oxygenases / antagonists & inhibitors*
  • Mixed Function Oxygenases / metabolism
  • Pediococcus / enzymology
  • Saccharomyces cerevisiae / enzymology

Substances

  • Enzyme Inhibitors
  • Mixed Function Oxygenases
  • Glucose Oxidase
  • Horseradish Peroxidase
  • lactate 2-monooxygenase
  • Hexokinase