A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load

PLoS One. 2020 Aug 14;15(8):e0237215. doi: 10.1371/journal.pone.0237215. eCollection 2020.

Abstract

In 1978, Thomas J. Sorensen defended a thesis in chemical engineering at the University of California, Berkeley, where he proposed an extensive model of glucose-insulin control, model which was thereafter widely employed for virtual patient simulation. The original model, and even more so its subsequent implementations by other Authors, presented however a few imprecisions in reporting the correct model equations and parameter values. The goal of the present work is to revise the original Sorensen's model, to clearly summarize its defining equations, to supplement it with a missing gastrio-intestinal glucose absorption and to make an implementation of the revised model available on-line to the scientific community.

MeSH terms

  • Algorithms
  • Blood Glucose / metabolism
  • Gastric Absorption
  • Gastric Mucosa / metabolism
  • Glucose / metabolism*
  • Humans
  • Insulin / metabolism*
  • Intestinal Absorption
  • Models, Biological

Substances

  • Blood Glucose
  • Insulin
  • Glucose

Grants and funding

The author(s) received no specific funding for this work.