Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments

Int Immunopharmacol. 2020 Nov:88:106885. doi: 10.1016/j.intimp.2020.106885. Epub 2020 Aug 8.

Abstract

The SARS-CoV-2 virus is an etiological agent of pandemic COVID-19, which spreads rapidly worldwide. No proven effective therapies currently exist for this virus, and efforts to develop antiviral strategies for the treatment of COVID-19 are underway. The rapidly increasing understanding of SARS-CoV-2 virology provides a notable number of possible immunological procedures and drug targets. However, gaps remain in our understanding of the pathogenesis of COVID-19. In this review, we describe the latest information in the context of immunological approaches and emerging current antiviral strategies for COVID-19 treatment.

Keywords: Antiviral strategies; COVID-19; Drug targets; Immunological approaches; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Viral / blood
  • Antiviral Agents / therapeutic use*
  • Betacoronavirus
  • COVID-19
  • COVID-19 Serotherapy
  • Clinical Trials as Topic
  • Coronavirus Infections / blood
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / therapy
  • Humans
  • Immunization, Passive
  • Pandemics
  • Pneumonia, Viral / blood
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / immunology*
  • SARS-CoV-2
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Antiviral Agents