The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

Jiaxin Tian; Yuan Xie; Meng Li; Julius Oatts; Ying Han; Yiquan Yang; Yan Shi; Yunxiao Sun; Jinghong Sang; Kai Cao; Chen Xin; Labisi Siloka; Huaizhou Wang; Ningli Wang

doi:10.3389/fphys.2020.00880

The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

Front Physiol. 2020 Jul 24:11:880. doi: 10.3389/fphys.2020.00880. eCollection 2020.

Authors

Jiaxin Tian¹, Yuan Xie¹, Meng Li¹, Julius Oatts², Ying Han², Yiquan Yang¹, Yan Shi¹, Yunxiao Sun¹, Jinghong Sang¹, Kai Cao¹, Chen Xin¹, Labisi Siloka¹, Huaizhou Wang¹, Ningli Wang¹

Affiliations

¹ Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.
² Department of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, United States.

Abstract

Objective: To evaluate whether the nailfold microcirculation is associated with retinal microcirculation in healthy subjects.

Methods: Fifty subjects without systematic and ocular diseases were enrolled. Thickness of peripapillary retinal nerve fiber layer (RNFL), vessel density (VD) of radial peripapillary capillaries (RPCs), and superficial capillary VD in macular zone were measured with optical coherence tomography angiography (OCTA) in left eyes. Nailfold microcirculation, including capillary density, avascular zones, dilated capillaries, and hemorrhages was examined on the fourth digit of each subject's non-dominant (left) hand with nailfold capillaroscopy (NFC).

Results: After adjustment for relatively systemic factors, multivariate regression analyses showed a significant direct relationship between RNFL thickness and nailfold capillary density (OR = 1.09; p = 0.046). RNFL thickness and RPCs VD were negatively correlated with nailfold avascular zones (OR = 0.855; p = 0.007; OR = 0.596; p = 0.010). Superficial VD of parafovea was negatively associated with dilated nailfold capillaries (OR = 0.794; p = 0.012).

Conclusion: In healthy subjects, nailfold capillary lower density and abnormalities are associated with reduced RNFL thickness and retinal VD. The results provide a theoretical foundation for relevant studies on ocular diseases with microvascular abnormalities and could contribute to pathogenesis understanding in the future. NFC and OCTA have the potential to identify risk factors and improve accuracy of the early diagnosis and treatment of ocular diseases, even systemic diseases with any microvascular component in clinical practice.

Clinical trail registration: http://www.chictr.org.cn/index.aspx, identifier ChiCTR 1800017875.

Keywords: nailfold capillaroscopy; nailfold microcirculation; optical coherence tomography angiography; relationship; retinal microcirculation.